Yoichi Isagi is the main protagonist of Blue Lock and is among the 300 players picked to compete in the Blue Lock Project. Previously a second-year football player at Ichinan High and now #299 in Blue Lock. He aspires to become a great hero like Noel Noa. Yoichi plays as a striker and is a team player. While playing football, Yoichi is great at remaining calm during pressure. He works with his teammates, but is capable of being selfish like a "true striker." He begins by competing in a high school match and as his team is desperate for a goal, he was found on a break away and 1-on-1 with the opposing goalkeeper in which he decided to pass to his teammate, and his teammate misses that led his team into missing out in the interhigh. He then regrets the play that he did and he then receives an invitation to the upcoming Blue Lock Project. This is the project that will soon change his life forever!

Midorima often acts reserved, mean, and brusque with others, coming off as arrogant—although Takao claims Midorima is just "tsundere." He has a hard time acting kind to his opponents and generally hates "fooling around" (although Takao often pursues him into it). He can be seen, at all times, with a lucky item due to his strong belief and passion for horoscope. He is left-handed, and always bandages his dominant hand outside of matches (claiming that his hand must be in perfect condition so nothing will influence his shot). He also shapes his nails so that his hands will be in perfect form for shooting. Formerly a member of the basketball team of Teikou Middle School, Midorima is a member of the Generation of Miracles (Kiseki no Sedai); during his time with Teikou, his jersey number was seven, switching to six as he joined Shūtoku's. He also served as a vice-captain under Akashi. His strength is his absolute accuracy, which is shown in his shots that always go in. He can shoot accurately no matter how far he is from the ring. He is also a really good defender (Source: Kuroko no Basket Wikia)