Misaki is the protagonist of Kaichou wa Maid-sama!. She lives alone with her mother and her younger sister Suzuna, because her father abandoned them, leaving them with a huge debt. Because of her father's actions, she has a deep hatred for most boys (except the gentlemanly type). She goes to Seika high school, which only recently became co-ed. It was an all-boy's school only a few years ago. Because of this, the student body is 80% male and 20% female. Misaki worked hard to become the student council president and "protect the girls." However, she has a secret. To help her mother pay off her father's debt, she has a part-time job...at a maid cafe! She doesn't want anyone at school to discover her, because she thinks that if they do, she will lose her authority as student council president.

She is a Lamia, a half human, half snake sub-species. She is the first to be Kimihito's ward when the cultural exchange began. She is sweet, naive and a carefree individual. She has a habit of being clingy when she sleeps. She's very ticklish when one holds the very tip of her tail, which is why Kimihito exploits that weakness in order to get out of her grip.